CPM works very well when the components of the design and the project are mostly known to all responsible parties. CPM focuses on either a single value-delivery event such as the completion of a building or in major phases such as turning over a floor at a time.  

CPM does not work as well in situations where there are significant “Known-Unknowns” about the plan CPM really breaks down when there are “Unknown-Unknowns”:

• The final destination isn’t crystal clear; even to the leader
• The path to get there has unknowns
• The tools and tactics required to get there aren’t known to the team

In these situations more agile management methods are required either in conjunction with or to replace CPM:

• Objectives & Key Results (OKRs)
• Lean Construction / Last Planner Systems (LPS)
• Continuous Improvement
• Agile PM Basics

There are similarities between all methods.  Develop the systems that work best for your company at this point in time.